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Year : 2019  |  Volume : 16  |  Issue : 1  |  Page : 56-57

Use of granulocyte colony-stimulating factor in recurrent implantation failures

IVF Department, Apollo Women's Hospital, Chennai, Tamil Nadu, India

Correspondence Address:
U Nagashree
Apollo Women's Hospital, Shafi Mohammed Raod, Thousand Lights, Chennai - 600 006, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/am.am_64_18

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In spite of significant advances in ART, recurrent implantation failures (RIFs) and miscarriages are challenging. These could be attributed to unfavorable endometrium/poor embryo quality. Regular priming with estrogen is done to improve endometrial thickness. Despite these, RIF and miscarriages most probably account for some immune-related problems too, normally classified as unexplained infertility. Several research groups reported increase in endometrial thickness and immunomodulatory functions of granulocyte colony-stimulating factor (GCSF) during in vitro fertilization cycles, in terms of achieving higher clinical pregnancy rates. More studies should be done in this context before resorting to gestational surrogacy. We report one such case of recurrent miscarriage and RIF which resulted in a successful pregnancy after intrauterine GCSF instillation into uterine cavity.

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