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Year : 2021  |  Volume : 18  |  Issue : 3  |  Page : 154-157

To evaluate efficacy of pregabalin for the prevention of etomidate-induced myoclonus: A prospective, randomized, placebo-controlled, double-blind study

1 Department of Anaesthesiology, Apollo Hospitals, Bilaspur, Chhattisgarh, India
2 Department of Anaesthesiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
3 Department of Anaesthesiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

Correspondence Address:
Vinit Kumar Srivastava
Department of Anaesthesiology, Apollo Hospitals, Bilaspur - 495 006, Chhattisgarh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/am.am_8_21

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Context: The incidence of myoclonus after etomidate induction is 50%–80%. The present study evaluated the efficacy of oral pregabalin for the prevention of etomidate-induced myoclonus. Settings and Design: A prospective, randomized, placebo-controlled, double-blind study. Subjects and Methods: Seventy-four patients of the American Society of Anesthesiologists physical status Grade I or II scheduled for elective surgery under anesthesia were recruited. Following exclusion, 66 patients were randomized into two groups. In Group P patients received pregabalin 150 mg orally 1 h before induction of anesthesia and in Group C patients received placebo tablet. The primary outcome was the incidence and severity of myoclonus. The secondary outcome was the postoperative sedation level. Results: The incidence and severity of myoclonus were significantly decreased in Group P compared with Group C (P < 0.05). The postoperative sedation score was significantly higher in Group P compared to Group C (P > 0.05). Conclusion: Pretreatment with pregabalin 150 mg orally reduced the incidence and severity of etomidate-induced myoclonus however incidence of sedation was more.

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