• Users Online: 304
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2022  |  Volume : 19  |  Issue : 4  |  Page : 251-255

SARS-CoV-2 Infection after Effects: Multi-Organ Damage through Oxygen Radicals


1 Department of Natural Products, National Institute of Pharmaceutical Education and Research; Department of Lab Services, Apollo Multi-Speciality Hospital; Department of Biochemistry, Jagannath Gupta Institute of Medical Sciences and Hospital, Budge-Budge, Kolkata, West Bengal, India
2 Department of Natural Products, National Institute of Pharmaceutical Education and Research, Kolkata, West Bengal, India
3 Department of Lab Services, Apollo Multi-Speciality Hospital, Kolkata, West Bengal, India
4 Department of Biochemistry, Jagannath Gupta Institute of Medical Sciences and Hospital, Budge-Budge, Kolkata, West Bengal, India
5 Department of Pathology, Apollo Hospitals Educational and Research Foundation, New Delhi, India

Correspondence Address:
Dr. Debatosh Datta
National Institute of Pharmaceutical Education and Research, Kolkata, West Bengal
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/am.am_122_22

Rights and Permissions

Introduction: SARS-CoV-2 respiratory infection leads to two-layered pathology in time (a) immediate pathology and recovery or fatal ending and (b) long periods of remission followed by unexplained clinical expressions involving one or more systems with various clinical presentations, even leading to loss of lives. Among the common causative factors affecting nearly all organs and systems, oxygen radicals and oxygen-derived species (ROS) should rank conclusively on top. Objective: This clinical report, part of a community screening of unexplained clinical outcomes in post-COVID presentation, carries findings focusing on ROS production and possible ROS-induced damages. Materials and Methods: Flow cytometry was used to quantify the samples' total ROS, superoxide production, and apoptosis quantification. Results: Observations indicate unexplained nearly uniform enhanced ROS production in all these long COVID subjects, although clinical presentations varied from no complaints to the requirement of advanced interventions. Conclusion: Causative factors leading to raised oxygen-derived toxic intermediaries (ROS) in initiating these variable long COVID presentations are ill-understood yet possibly merit mass screenings and possible intense anti-oxidative therapy given that such antioxidant therapy through oral medications led to rapid lowering of ROS production and improvement of clinical presentations.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed608    
    Printed24    
    Emailed0    
    PDF Downloaded28    
    Comments [Add]    

Recommend this journal