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Year : 2022  |  Volume : 19  |  Issue : 4  |  Page : 267-269

Factor XI deficiency case reports on congenital and acquired Hemophilia C - A case report

1 Department of Haematology and Clinical Pathology, Apollo Hospitals, Chennai, Tamil Nadu, India
2 Department of Clinical Haematology, Apollo Hospitals, Chennai, Tamil Nadu, India

Correspondence Address:
Dr. Mamta Soni
Department of Haematology and Clinical Pathology, Apollo Hospitals, 21 Greams Lane, Off Greams Road, Chennai - 600 031, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/am.am_108_22

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Introduction: Factor XI deficiency or hemophilia C is a very rare coagulation factor deficiency, with a global incidence of 1 in 1 million. Although it is an under-recognized entity, it can cause significant bleeding, resulting in life-threatening complications. Materials and Methods: Coagulation parameters were analyzed using a Sysmex CS-2400 coagulation analyzer. Factor XI levels were detected using Factor XI deficient plasma from Siemens. Activated Partial Thromboplastin Time (APTT) testing was performed using Actin FSL from Siemens. Results: Here, we report the two cases of Factor XI deficiency, one genetic and the other a very rare acquired deficiency due to sepsis, detected during the workup of an isolated APTT prolongation. Conclusion: Factor XI deficiency is a rare bleeding disorder that presents as prolonged isolated APTT. Careful clinical evaluation and complete coagulation workup are necessary for the efficient management of patients, which can prevent life-threatening events.

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