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Spuriously low thyroid-stimulating hormone? A laboratory phenomenon

1 Department of Biochemistry, Apollo Hospitals, Chennai, Tamil Nadu, India
2 Department of Hematology and Clinical Pathology, Apollo Hospitals, Chennai, Tamil Nadu, India

Correspondence Address:
Mamta Soni,
Department of Hematology and Clinical Pathology, Apollo Hospitals, 21 Greams Lane, Off. Greams Road, Chennai - 600 031, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/am.am_81_22

Thyroid gland is an endocrine gland with vital functions regulating metabolism, growth, and development. The tests used to assess the functions of the thyroid gland include thyroid-stimulating hormone (TSH), free thyroxine, and free tri-iodothyronine. TSH is routinely measured in the clinical laboratory with automated immunoassays to diagnose and monitor thyroid disorders. We present a case wherein the discrepancy between the clinical symptoms and the biochemical test results raised the possibility of methodological interference in laboratory testing, finally leading to a detection of a rare genetic mutation in the patient. This case reiterates that clinical correlation of laboratory results and effective communication between the clinician and the laboratory are imperative for a correct diagnosis and therapeutic interventions.

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