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Diagnosis of AL amyloidosis on bone marrow aspirate smears - A Case Report

1 Department of Hematology and Clinical Pathology, Cardiology Apollo Hospital, Chennai, Tamil Nadu, India
2 Department of Clinical Haematology, Cardiology Apollo Hospital, Chennai, Tamil Nadu, India
3 Department of Internal Medicine, Cardiology Apollo Hospital, Chennai, Tamil Nadu, India

Correspondence Address:
Mamta Soni,
Department of Haematology and Clinical Pathology, Apollo Hospital, Greams Road, Chennai - 600 031, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/am.am_50_22

Introduction: An amyloidosis is a group of diseases associated with the deposition of abnormal protein fibrils in the tissues. Primary amyloidosis (AL) type is the most common form of systemic amyloidosis encountered in clinical settings resulting from the deposition of abnormal light chains associated with underlying plasma cell dyscrasia. Amyloid deposits are rarely seen in bone marrow aspirate smears. Methods: Amyloidosis occurs as a result of the deposition of autologous proteins, which, when viewed under a light microscope, appear as eosinophilic, acellular, amorphous deposits. Results: We presented a case of AL amyloidosis presenting with cardiac manifestations and detected to have amyloid deposits in bone marrow aspirates. Conclusion: To the best of our knowledge, reporting amyloid deposition in bone marrow aspirate smears is very rare and unusual, with sparse mention of its occurrence in literature. Careful examination of bone marrow aspirate for this striking finding leads us to a quicker diagnosis of amyloidosis for a prompt determination of therapeutic protocol, improving the outcomes for the patients.

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