Apollo Medicine

CASE REPORT
Year
: 2019  |  Volume : 16  |  Issue : 1  |  Page : 56--57

Use of granulocyte colony-stimulating factor in recurrent implantation failures


U Nagashree, Sumana Manohar 
 IVF Department, Apollo Women's Hospital, Chennai, Tamil Nadu, India

Correspondence Address:
U Nagashree
Apollo Women's Hospital, Shafi Mohammed Raod, Thousand Lights, Chennai - 600 006, Tamil Nadu
India

In spite of significant advances in ART, recurrent implantation failures (RIFs) and miscarriages are challenging. These could be attributed to unfavorable endometrium/poor embryo quality. Regular priming with estrogen is done to improve endometrial thickness. Despite these, RIF and miscarriages most probably account for some immune-related problems too, normally classified as unexplained infertility. Several research groups reported increase in endometrial thickness and immunomodulatory functions of granulocyte colony-stimulating factor (GCSF) during in vitro fertilization cycles, in terms of achieving higher clinical pregnancy rates. More studies should be done in this context before resorting to gestational surrogacy. We report one such case of recurrent miscarriage and RIF which resulted in a successful pregnancy after intrauterine GCSF instillation into uterine cavity.


How to cite this article:
Nagashree U, Manohar S. Use of granulocyte colony-stimulating factor in recurrent implantation failures.Apollo Med 2019;16:56-57


How to cite this URL:
Nagashree U, Manohar S. Use of granulocyte colony-stimulating factor in recurrent implantation failures. Apollo Med [serial online] 2019 [cited 2023 Jan 31 ];16:56-57
Available from: https://apollomedicine.org/article.asp?issn=0976-0016;year=2019;volume=16;issue=1;spage=56;epage=57;aulast=Nagashree;type=0