Factor XI deficiency case reports on congenital and acquired Hemophilia C - A case report :Mamta Soni, Srikanth Muralikrishnan, Supraja Sundaram, Apollo Medicine

CASE REPORT
Year : 2022 | Volume : 19 | Issue : 4 | Page : 267--269

Factor XI deficiency case reports on congenital and acquired Hemophilia C - A case report

Mamta Soni¹, Srikanth Muralikrishnan², Supraja Sundaram¹
¹ Department of Haematology and Clinical Pathology, Apollo Hospitals, Chennai, Tamil Nadu, India
² Department of Clinical Haematology, Apollo Hospitals, Chennai, Tamil Nadu, India

Correspondence Address:
Dr. Mamta Soni
Department of Haematology and Clinical Pathology, Apollo Hospitals, 21 Greams Lane, Off Greams Road, Chennai - 600 031, Tamil Nadu
India

Introduction: Factor XI deficiency or hemophilia C is a very rare coagulation factor deficiency, with a global incidence of 1 in 1 million. Although it is an under-recognized entity, it can cause significant bleeding, resulting in life-threatening complications. Materials and Methods: Coagulation parameters were analyzed using a Sysmex CS-2400 coagulation analyzer. Factor XI levels were detected using Factor XI deficient plasma from Siemens. Activated Partial Thromboplastin Time (APTT) testing was performed using Actin FSL from Siemens. Results: Here, we report the two cases of Factor XI deficiency, one genetic and the other a very rare acquired deficiency due to sepsis, detected during the workup of an isolated APTT prolongation. Conclusion: Factor XI deficiency is a rare bleeding disorder that presents as prolonged isolated APTT. Careful clinical evaluation and complete coagulation workup are necessary for the efficient management of patients, which can prevent life-threatening events.

How to cite this article:
Soni M, Muralikrishnan S, Sundaram S. Factor XI deficiency case reports on congenital and acquired Hemophilia C - A case report.Apollo Med 2022;19:267-269

How to cite this URL:
Soni M, Muralikrishnan S, Sundaram S. Factor XI deficiency case reports on congenital and acquired Hemophilia C - A case report. Apollo Med [serial online] 2022 [cited 2023 Mar 22 ];19:267-269
Available from: https://apollomedicine.org/article.asp?issn=0976-0016;year=2022;volume=19;issue=4;spage=267;epage=269;aulast=Soni;type=0